Protection from Feed-Forward Amplification in an Amplified RNAi Mechanism

Abstract

The effectiveness of RNA interference (RNAi) in many organisms is potentiated through the signal-amplifying activity of a targeted RNA-directed RNA polymerase (RdRP) system that can convert a small population of exogenously-encountered dsRNA fragments into an abundant internal pool of small interfering RNA (siRNA). As for any biological amplification system… (More)
DOI: 10.1016/j.cell.2012.10.022

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