Protection from 1,1-dichloroethylene-induced Clara cell injury by diallyl sulfone, a derivative of garlic.

@article{Forkert1996ProtectionF1,
  title={Protection from 1,1-dichloroethylene-induced Clara cell injury by diallyl sulfone, a derivative of garlic.},
  author={P. G. Forkert and R P Lee and T F Dowsley and Jungil Hong and Judith B. Ulreich},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1996},
  volume={277 3},
  pages={1665-71}
}
Bronchiolar Clara cell damage ensues after treatment of mice with 1,1-dichloroethylene (DCE). The cytotoxicity is mediated by CYP2E1, a cytochrome P450 isozyme that is highly localized in the Clara cells. Bioactivation of DCE produces the primary metabolites 2,2-dichloroacetaldehyde, which hydrolyzes to the acetal, and DCE epoxide, which reacts with glutathione to form the conjugates 2-(S-glutathionyl) acetyl glutathione [B] and 2-S-glutathionyl acetate [C]. In this study, we investigated the… CONTINUE READING