Protection by vascular endothelial growth factor against sinusoidal endothelial damage and apoptosis induced by cold preservation.

@article{Moriga2000ProtectionBV,
  title={Protection by vascular endothelial growth factor against sinusoidal endothelial damage and apoptosis induced by cold preservation.},
  author={Takeo Moriga and Shigeki Arii and Yasutaka Takeda and Hiroaki Furuyama and Masaki Mizumoto and Akio Mori and Kiyotaka Hanaki and Takayuki Nakamura and Makio Fujioka and Mitsutoshi Imamura},
  journal={Transplantation},
  year={2000},
  volume={69 1},
  pages={
          141-7
        }
}
BACKGROUND It is well known that sinusoidal endothelial cell (SEC) damage during cold preservation of liver tissue is closely involved in early graft failure. The objective of this study was to investigate the involvement of apoptosis in the SEC damage induced by cold preservation and to demonstrate the protective effect of vascular endothelial growth factor (VEGF) on SEC injury, including apoptotic changes. METHODS Isolated SECs and liver tissue of Wistar rats were cold-preserved in… CONTINUE READING

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