Protection by the calcium antagonist Wy-47,037 against stress ulceration in the rat.

Abstract

Wy-47,037, a novel compound with both intracellular and extracellular calcium-blocking properties, was evaluated for its effects on cold/restraint stress induced ulceration in the rat. Wy-47,037 dose-dependently inhibited ulcerogenesis; with an ED50 of 8 mg/kg, PO, it was approximately twice as potent as nitrendipine (ED50 = 15 mg/kg). Wy-47,037 also reduced basal gastric acid secretion (ED50 = 7 mg/kg) and gastrointestinal motility (ED50 = 16 mg/kg). It is thus possible that Wy-47,037's alteration of basal gastric acid secretion and/or of gastrointestinal motility may contribute to its therapeutic efficacy against stress induced ulcer formation.

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@article{Nielsen1988ProtectionBT, title={Protection by the calcium antagonist Wy-47,037 against stress ulceration in the rat.}, author={Sara Trab Nielsen and Theodore S Sulkowski}, journal={Pharmacology, biochemistry, and behavior}, year={1988}, volume={29 1}, pages={129-32} }