Protection by steroids against acute HgCl2 poisoning

  title={Protection by steroids against acute HgCl2 poisoning},
  author={Hans Selye and Imre M{\'e}cs and S{\'a}ndor Szab{\'o}},
  journal={International Urology and Nephrology},
Experiments on rats indicate that the fatal renal damage normally produced by acute HgCl2 intoxication is more effectively prevented by thioacetyl containing steroids (e.g., spironolactone, spiroxasone or emdabol) than by inorganic sodium thioacetate. Steroids possesing sulfur in forms other than thioacetyl, as well as steroids devoid of sulfur, did not protect against acute HgCl2 intoxication under our experimental conditions. Among a large series of organic and inorganic sulfur compounds… 
3 Citations

Resistenz des Nierengewebes gegen Dichromatschäden nach Folsäureinjektion

It is suggested that a change from functional to proliferative metabolism might be the most important cause of this folate induced resistance of kidneys and decreased transport of the nephrotoxin might be responsible for this protection against renal lesions.

Renal Injury and Urinary Excretion

The sections in this article are: Acute Renal Failure, Nephrotic Syndrome and Tubular Dysfunction, Factors Affecting Renal Toxicity and Excretion, and Factors affected by Complexing Agents.

Protection by catatoxic steroids against cyclophosphamide-induced organ lesions

In rats, fatal cyclophosphamide intoxication can be prevented by certain catatoxic steroids, particularly PN (pregnenolone-16α-nitrile), SC-11927 and spironolactone, and phenobarbital, the prototype of nonsteroidal cat atoxic compounds, does not protect against cycloph phosphamide.



Prevention of digitoxin poisoning by various steroids.

Experiments on rats indicate that spironolactone as well as several anabolic androgens protect the rat against an otherwise fatal digitoxin poisoning, whereas numerous other hormonally active or

Resistance to picrotoxin poisoning induced by catatoxic steroids

  • H. Selye
  • Medicine, Biology
    Agents and Actions
  • 2005
There appears to be a close relationship between the ability of various steroids to protect against picrotoxin convulsions and their catatoxic actions previously observed in other test systems.

Resistance to various pesticides induced by catatoxic steroids.

  • H. Selye
  • Biology
    Archives of environmental health
  • 1970
DDT, physostigmine sulfate and pralidoxime chloride, tested for comparative purposes, proved to be much more resistant against detoxication by even the most powerful catatoxic steroids.


Pretreatment with various steroids can protect the rat against the induction of anesthesia by progesterone or pentobarbital, but such hormonal potency does not appear to be indispensable for this protective effect since spironolactone is highly efficacious in antagonizing both anesthetics employed in this work.

Pharmacological implications of microsomal enzyme induction.

  • A. Conney
  • Biology, Medicine
    Pharmacological reviews
  • 1967
It is of considerable interest that certain inducers of liver microsomal enzymes have recently been used therapeutically for the treatment of hyperbilirubinemia in jaundiced children and for thetreatment of Cushing's syndrome.

Mercury Poisoning: Prevention by Spironolactone

The renal tubular necrosis and calcification as well as the mortality induced by mercuric chloride in the rat are readily prevented by prior treatment with well-tolerated amounts of spironolactone.

Increased Hepatic Microsomal Activity Induced by Spironolactone and Other Steroids 1

  • B. SolymossH. ClassenS. Varga
  • Medicine, Biology
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
  • 1969
Summary In the rat, pretreatment with spironolactone, norbolethone, or ethylestrenol increased the oxidation of pentobarbital by liver microsomes, enhanced its disappearance from blood and

Prevention by Spironolactone of 7,12-Dimethylbenz(a)anthracene-induced Adrenal Necrosis∗

  • K. KovácsÁ. Somogyi
  • Biology
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
  • 1969
Administration of spironolactone protects the rat against 7,12-dimethylbenz-induced adrenal necrosis and prevents anthracene-induced Adrenal Necrosis.

Prevention of indomethacin-induced intestinal ulcers by spironolactone and norbolethone.

  • H. Selye
  • Medicine
    Canadian journal of physiology and pharmacology
  • 1969
Both spironolactone and norbolethone protect the rat against the production of multiple intestinal ulcers and peritonitis by indomethacin.