Protection by dietary zinc in ALS mutant G93A SOD transgenic mice.

@article{Ermilova2005ProtectionBD,
  title={Protection by dietary zinc in ALS mutant G93A SOD transgenic mice.},
  author={Irina P Ermilova and Vladimir B Ermilov and Mark Levy and Emily E. Ho and C de E Pereira and Joseph S. Beckman},
  journal={Neuroscience letters},
  year={2005},
  volume={379 1},
  pages={42-6}
}
Mutations to the copper, zinc superoxide dismutase (SOD) gene are responsible for 2-3% of amyotrophic lateral sclerosis (ALS) cases. These mutations result in the protein having a reduced affinity for zinc. SOD becomes toxic to motor neurons when zinc is missing from its active site. Recently, high dosages of zinc (75 and 375 mg/kg/day) have been… CONTINUE READING