Protection by amifostine of cyclophosphamide-induced myelosuppression.

The dose and schedule of administration of chemotherapeutic agents are often dictated by their bone marrow toxicity. Cumulative bone marrow damage may be associated with chronic exposure to chemotherapeutic agents such as alkylating agents. Amifostine (Ethyol; Alza Pharmaceuticals, Palo Alto, CA/US Bioscience, West Conshohocken, PA), a cytoprotective agent… CONTINUE READING