Protection by a manganese porphyrin of endogenous peroxynitrite-induced death of glial cells via inhibition of mitochondrial transmembrane potential decrease.

@article{Choi2000ProtectionBA,
  title={Protection by a manganese porphyrin of endogenous peroxynitrite-induced death of glial cells via inhibition of mitochondrial transmembrane potential decrease.},
  author={In-Geol Choi and Sun Jung Lee and Chuanxia Ju and Wonwoo Nam and Hyoung Chun Kim and Kwang Ho Ko and Won Ki Kim},
  journal={Glia},
  year={2000},
  volume={31 2},
  pages={155-64}
}
In the cerebral ischemic penumbra, progressive metabolic deterioration eventually leads to death of glial cells. The exact mechanism for the death of glial cells is unclear. Here we report that under glucose-deprived conditions immunostimulated glial cells rapidly underwent death via production of large amounts of peroxynitrite. The cell-permeable Mn(III)tetrakis(N-methyl-4'-pyridyl)porphyrin (MnTMPyP) caused a concentration-dependent attenuation of the increased death in glucose-deprived… CONTINUE READING