Protection by Chrysanthemum zawadskii extract from liver damage of mice caused by carbon tetrachloride is maybe mediated by modulation of QR activity

@article{Seo2010ProtectionBC,
  title={Protection by Chrysanthemum zawadskii extract from liver damage of mice caused by carbon tetrachloride is maybe mediated by modulation of QR activity},
  author={Ji Yeon Seo and Soon Sung Lim and Jia Park and Ji Sun Lim and Hyo Jung Kim and Hui Jung Kang and Jung Han Yoon Park and Jong-Sang Kim},
  journal={Nutrition Research and Practice},
  year={2010},
  volume={4},
  pages={93 - 98}
}
Our previous study demonstrated that methanolic extract of Chrysanthemum zawadskii Herbich var. latilobum Kitamura (Compositae) has the potential to induce detoxifying enzymes such as NAD(P)H:(quinone acceptor) oxidoreductase 1 (EC 1.6.99.2) (NQO1, QR) and glutathione S-transferase (GST). In this study we further fractionated methanolic extract of Chrysanthemum zawadskii and investigated the detoxifying enzyme-inducing potential of each fraction. The fraction (CZ-6) shown the highest QR… 

Figures from this paper

Chrysanthemi Flos extract alleviated acetaminophen-induced rat liver injury via inhibiting oxidative stress and apoptosis based on network pharmacology analysis
TLDR
It is demonstrated that BZE protected rats from APAP-induced liver injury through antioxidant and anti-apoptotic pathways, suggesting BZE could be further developed as a potential liver-protecting agent.
Ethanol extract of Chrysanthemum zawadskii Herbich induces autophagy and apoptosis in mouse colon cancer cells through the regulation of reactive oxygen species
TLDR
It was confirmed that ECZ induced ROS-mediated autophagy and apoptosis in colon cancer cells, and may serve as a novel potential chemotherapeutic candidate for colon cancer.
Inhibitory Effects of Eriodictyol-7-O-β-d-glucuronide and 5,7-Dihydroxy-4-chromene Isolated from Chrysanthemum zawadskii var. latilobum in FcεRI-Mediated Human Basophilic KU812F Cell Activation
TLDR
Results suggested that EDG and DC, antiallergic constituents of CZL, are potential therapeutic candidates for protection against and for the treatment of allergic disorders.
6-Methoxyluteolin from Chrysanthemum zawadskii var. latilobum suppresses histamine release and calcium influx via down-regulation of FcεRI α chain expression.
TLDR
Results show that 6- methoxyluteolin is a potent inhibitor of histamine release and calcium influx via down-regulation of the FcεRI α chain.
Isolation and identification of flavonoids from Gujeolcho (Chrysanthemum zawadskii var. latilobum) as inhibitor of histamine release
TLDR
Results suggest that gujeolcho extracts and 3 compounds would be candidates as therapeutic or preventive agents for allergic reaction.
Inhibitory Effect of Chrysanthemum zawadskii Herbich var. latilobum Kitamura Extract on RANKL-Induced Osteoclast Differentiation
TLDR
Results indicate that CZE negatively regulates osteoclast differentiation and may be a therapeutic candidate for the treatment of various bone diseases, such as postmenopausal osteoporosis, rheumatoid arthritis, and periodontitis.
구절초의 추출조건에 따른 Linarin 함량과 In Vitro 생리활성 변화
This study was designed to determine optimal extraction conditions of Chrysanthemum zawadskii (CZ) with high yield of bioactive compounds (linarin, polyphenols, and flavonoids) and improved in vitro
Hypoglycemic effect of standardized Chrysanthemum zawadskii ethanol extract in high-fat diet/streptozotocin-induced diabetic mice and rats
TLDR
Results suggest that CZE may be a potential candidate for controlling hyperglycemia and decrease components of the serum lipid profile such as triglyceride, total cholesterol, and low-density lipoprotein cholesterol levels.
...
...

References

SHOWING 1-10 OF 29 REFERENCES
Isoalantolactone from Inula helenium caused Nrf2-mediated induction of detoxifying enzymes.
TLDR
Investigation of the detoxifying enzyme-inducing potential of isoalantolactone found it to be a candidate for chemoprevention and acts as potent phase 2 enzyme inducer by stimulating the accumulation of Nrf2 in the nucleus.
Induction of the anticarcinogenic marker enzyme, quinone reductase, by Dalbergiae Lignum
TLDR
The effect of an extract of Dalbergiae Lignum and four components that were isolated from the extract on the anticarcinogenic phase II marker enzyme, quinone reductase (QR), was investigated and the CH2Cl2 fraction was the most potent in inducing QR activity.
A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure.
TLDR
Sulforaphane is the most potent inducer, and the presence of oxygen on sulfur enhances potency, which may be a significant component of the anticarcinogenic action of broccoli.
Nrf2‐mediated induction of detoxifying enzymes by alantolactone present in Inula helenium
TLDR
Alantolactone appears to induce detoxifying enzymes via activation of PI3K and JNK signaling pathways, leading to translocation of NRF2, and subsequent interaction between Nrf2 and ARE in the encoding genes.
Increase of NAD(P)H:quinone reductase by dietary antioxidants: possible role in protection against carcinogenesis and toxicity.
TLDR
The protective effects of BHA appear to be due, at least in part, to the ability of this antioxidant to increase the activities in rodent tissues of several enzymes involved in the nonoxidative metabolism of a wide variety of xenobiotics.
Cytotoxic Flavonoids from the Whole Plants of Chrysanthemum zawadskii Herbich var. latilobum Kitamura
Two known flavonoids, luteolin (1) and acacetin (2) were isolated from a CHCl₃ soluble fraction of the whole plants of Chrysanthemum zawadskii Herbich var. latilobum Kitamura, and their structures
On the mechanisms of induction of cancer-protective enzymes: a unifying proposal.
TLDR
The findings suggest that the functional capacity to form quinones or quinone-diimines, rather than the precise structure, is essential for inductive activity and that the generation of the signal for enzyme induction depends upon oxidation-reduction lability.
Effects of glutathione on antioxidant response element-mediated gene expression and apoptosis elicited by sulforaphane.
TLDR
The results suggest that the biological effects of SFN and SFN-NAC on the induction of ARE-related gene expression and apoptosis could be different from each other; however, the different effects on ARE- related gene expressionand apoptosis elicited by SFN can be blocked by the addition of GSH.
Resistance to carbon tetrachloride-induced hepatotoxicity in mice which lack CYP2E1 expression.
TLDR
It is conclusively demonstrated that CYP2E1 is the major factor involved in the CCl4-induced hepatotoxicity in mice.
Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element.
TLDR
It is demonstrated that induction of HO-1 by curcumin and CAPE requires the activation of the Nrf2/ARE pathway, and using antibodies and specific inhibitors of the mitogen-activated protein kinase (MAPK) pathways, data is provided implicating p38 MAPK inCurcumin-mediated ho-1 induction.
...
...