Protection by Anti-β-Glucan Antibodies Is Associated with Restricted β-1,3 Glucan Binding Specificity and Inhibition of Fungal Growth and Adherence

@article{Torosantucci2009ProtectionBA,
  title={Protection by Anti-β-Glucan Antibodies Is Associated with Restricted β-1,3 Glucan Binding Specificity and Inhibition of Fungal Growth and Adherence},
  author={Antonella Torosantucci and Paola Chiani and Carla Bromuro and Flavia de Bernardis and Angelina S. Palma and Yan Liu and Giuseppina Mignogna and Bruno Maras and Marisa Colone and Annarita Stringaro and Silvia Zamboni and Maria Helena S. Goldman and Antonio Cassone},
  journal={PLoS ONE},
  year={2009},
  volume={4},
  pages={i5 - i11}
}
Anti-beta-glucan antibodies elicited by a laminarin-conjugate vaccine confer cross-protection to mice challenged with major fungal pathogens such as Candida albicans, Aspergillus fumigatus and Cryptococcus neoformans. To gain insights into protective beta-glucan epitope(s) and protection mechanisms, we studied two anti-beta-glucan monoclonal antibodies (mAb) with identical complementarity-determining regions but different isotypes (mAb 2G8, IgG2b and mAb 1E12, IgM). C. albicans, the most… CONTINUE READING

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References

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SHOWING 1-10 OF 92 REFERENCES

A novel glyco-conjugate vaccine against fungal pathogens

  • The Journal of experimental medicine
  • 2005
VIEW 10 EXCERPTS
HIGHLY INFLUENTIAL

Intravaginal and intranasal immunizations are equally effective in inducing vaginal antibodies and conferring protection against vaginal candidiasis

F De Bernardis, M Boccanera, D Adriani, A Girolamo, A Cassone
  • Infect Immun
  • 2002
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Antimicrobial resistance: resistance to antifungal agents: mechanisms and clinical impact.

  • Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2008
VIEW 1 EXCERPT

Candida albicans cell wall comprises a branched beta-d-(1R6)-glucan with beta-d-(1R3)side chains

E Iorio, A Torosantucci, C Bromuro, P Chiani, A Ferretti
  • Carbohydr Res
  • 2008
VIEW 2 EXCERPTS