Protection and susceptibility

  title={Protection and susceptibility},
  author={Kevin Davies},
  • K. Davies
  • Published 1 April 1993
  • Medicine
  • Nature
The association between insulin-dependent diabetes mellitus and HLA is fearsomely complicated. But powerful techniques are being brought to bear on the problem. 
Mapping the genes for IgE production and allergy.
  • D. Marsh
  • Biology, Medicine
    Advances in experimental medicine and biology
  • 1996
The picture of allergic disease that is emerging is one comprised of overlapping constellations of genes that interact in an indefinitely large number of ways with a wide variety of environmental factors.
Butterfly-shaped macular dystrophy. Longitudinal case study of two siblings.
The present observations emphasize that BSMD, at least in some cases, can be a chronic progressive disorder with secondary involvement of the photoreceptors.
Comparative analysis of cultivated melon groups (Cucumis melo L.) using random amplified polymorphic DNA and simple sequence repeat markers
Results of RAPD marker analysis suggest that 80 marker bands were adequate for assessing the genetic variation present in the accessions examined, and that, per band, lower coefficients of variation can be attained in the estimation of GD when using RAPDs compared to SSRs.
Mono-nucleotide repeats (MNRs): a neglected polymorphism for generating high density genetic maps in silico
MNRs have potential for in silico saturation of sequenced eukaryote genomes with informative genetic markers, and a rapid method was developed, based on sizing of fluorescent-labeled primer extension products, to enable practical, high throughput MNR genotyping.
Barley microsatellites: allele variation and mapping
A database search of 228 barley sequences from GenBank and EMBL was made to determine which simple sequence repeat (SSR) motif prevails in barley, and nearly all types of SSRs were found.
Editor's Choice - Fluid-Structure Interaction Simulations of Aortic Dissection with Bench Validation.
  • H. Chen, S. Peelukhana, G. Kassab
  • Biology, Engineering
    European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery
  • 2016


Genetic control of autoimmunity in type 1 diabetes.
  • J. Todd
  • Biology, Medicine
    Immunology today
  • 1990
Genetic dissection of autoimmune type I diabetes in the BB rat
Based on genetic analysis of several crosses, it is shown that development of diabetes involves at least three genes: Lyp, which is tightly linked to the neuropeptide Y (Npy) gene on chromosome 4, a gene link to the major histocompatibility complex (MHC) on chromosome 20, and a third unmapped gene for which the Fischer rat strain carries an allele conferring resistance.
Insulin gene region–encoded susceptibility to type 1 diabetes is not restricted to HLA–DR4–positive individuals
Evidence for linkage of INS to IDDM is found in both male and female meioses and that the effect of the susceptibility gene(s) in the INS region is not dependent on the presence of HLA–DR4.
HLA class II alleles and susceptibility and resistance to insulin dependent diabetes mellitus in Mexican-American families
The general pattern of neutral and protective haplotypes indicates that the presence of Asp-57 in the HLA-DQβ chain does not confer IDDM protection per se and indicates that both DRB1 and DQB1 influence IDDM susceptibility as well as protection.
Familial hyperglycemia due to mutations in glucokinase. Definition of a subtype of diabetes mellitus.
Mutations in glucokinase are the primary cause of hyperglycemia in a substantial fraction of French patients with maturity-onset diabetes of the young and result in a relatively mild form of NIDDM that can be diagnosed in childhood.
Interaction between T cell receptor beta chain and immunoglobulin heavy chain region genes in susceptibility to insulin-dependent diabetes mellitus.
Evidence is reported for an IDDM-TCRB relationship which is dependent on immunoglobulin heavy-chain-region genes and the TCRB-Gm-IDDM and HLA- Gm- IDDM interaction effects may be functionally related.
Nonsense mutation in the glucokinase gene causes early-onset non-insulin-dependent diabetes mellitus
The identification of a nonsense mutation in the gene encoding glucokinase and its linkage with early-onset diabetes in one family is reported, the first evidence implicating a mutation in a gene involved in glucose metabolism in the pathogenesis of NIDDM.
Missense glucokinase mutation in maturity–onset diabetes of the young and mutation screening in late–onset diabetes
The discovery that glucokinase mutations can cause MODY and was also found in ten affected members of a pedigree with type 2 diabetes in which MODY had not previously been considered indicates that diagnosis based on molecular pathology will be helpful in understanding the aetiology of type 1 diabetes.
Human glucokinase gene: isolation, characterization, and identification of two missense mutations linked to early-onset non-insulin-dependent (type 2) diabetes mellitus.
The identification of mutations in glucokinase, a protein that plays an important role in hepatic and beta-cell glucose metabolism, indicates that early-onset non-insulin-dependent diabetes mellitus may be primarily a disorder of carbohydrate metabolism.
Map of the human MHC.