Protection and immune responses induced by attenuated Salmonella typhimurium UK-1 strains.

@article{Zhang1999ProtectionAI,
  title={Protection and immune responses induced by attenuated Salmonella typhimurium UK-1 strains.},
  author={Xiaochun Zhang and Sandra M. Kelly and Wendy S Bollen and Roy Curtiss},
  journal={Microbial pathogenesis},
  year={1999},
  volume={26 3},
  pages={121-30}
}
We previously reported that Salmonella typhimurium SR-11 mutants with deletion mutations in the genes encoding adenylate cyclase (cya) and the cAMP receptor protein (crp) are avirulent and protective in mice. Salmonella typhimurium UK-1 is highly virulent for chicks (oral LD50 of 3x10(3) CFU) and mice (oral LD50 of 8.5x10(3) CFU) and is capable of lethal infections in pigs, calves and horses. We postulated that attenuated derivatives of this lethal strain would probably induce a higher level of… CONTINUE READING