Protection against superoxide and hydrogen peroxide in synovial fluid from rheumatoid patients.

@article{Blake1981ProtectionAS,
  title={Protection against superoxide and hydrogen peroxide in synovial fluid from rheumatoid patients.},
  author={DavidR. Blake and Nick D. Hall and D A Treby and Barry Halliwell and JohnM. C. Gutteridge},
  journal={Clinical science},
  year={1981},
  volume={61 4},
  pages={
          483-6
        }
}
1. On exposure of synovial fluid to superoxide and hydrogen peroxide, generated enzymically or by activated polymorphonuclear leucocytes, hyaluronic acid is depolymerized and the fluid loses its lubricating properties. The ability of synovial fluid from rheumatoid patients to scavenge superoxide and hydrogen peroxide was therefore examined. 2. Synovial fluid from a range of rheumatoid patients contained no superoxide dismutase activity, insufficient caeruloplasmin to scavenge any superoxide… CONTINUE READING

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