Protection against simian/human immunodeficiency virus (SHIV) 89.6P in macaques after coimmunization with SHIV antigen and IL-15 plasmid.

@article{Boyer2007ProtectionAS,
  title={Protection against simian/human immunodeficiency virus (SHIV) 89.6P in macaques after coimmunization with SHIV antigen and IL-15 plasmid.},
  author={Jean D. Boyer and Tara M. Robinson and Michele A. Kutzler and Gordon Vansant and David A. Hokey and Sanjeev Kumar and Rose M. Parkinson and Ling Wu and Maninder K. Sidhu and George N Pavlakis and Barbara K Felber and Charles Brown and Peter M Silvera and Mark G. Lewis and Joseph Monforte and Thomas A. Waldmann and John Eldridge and David B. Weiner},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 47},
  pages={18648-53}
}
The cell-mediated immune profile induced by a recombinant DNA vaccine was assessed in the simian/HIV (SHIV) and macaque model. The vaccine strategy included coimmunization of a DNA-based vaccine alone or in combination with an optimized plasmid encoding macaque IL-15 (pmacIL-15). We observed strong induction of vaccine-specific IFN-gamma-producing CD8(+) and CD4(+) effector T cells in the vaccination groups. Animals were subsequently challenged with 89.6p. The vaccine groups were protected from… CONTINUE READING
37 Citations
4 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 37 extracted citations

References

Publications referenced by this paper.
Showing 1-4 of 4 references

Microbes Infect 5:227–231

  • J Sprent
  • 2003

Arthritis Res 4:S161–S167

  • T Waldmann
  • 2002

Matrix Biol 17:335–347

  • YT Konttinen, S Halinen, +7 authors A Larsson
  • 1998

Arthritis Rheum 39:1576–1587

  • D Ahrens, AE Koch, RM Pope, M Stein-Picarella, MJ Niedbala
  • 1996

Similar Papers

Loading similar papers…