Protection against renal ischemia–reperfusion injury in vivo by the mitochondria targeted antioxidant MitoQ

@inproceedings{Dare2015ProtectionAR,
  title={Protection against renal ischemia–reperfusion injury in vivo by the mitochondria targeted antioxidant MitoQ},
  author={Anna J. Dare and Eleanor A. Bolton and Gavin J. Pettigrew and J Andrew Bradley and Kourosh Saeb-Parsy and Michael P Murphy},
  booktitle={Redox biology},
  year={2015}
}
Ischemia-reperfusion (IR) injury to the kidney occurs in a range of clinically important scenarios including hypotension, sepsis and in surgical procedures such as cardiac bypass surgery and kidney transplantation, leading to acute kidney injury (AKI). Mitochondrial oxidative damage is a significant contributor to the early phases of IR injury and may initiate a damaging inflammatory response. Here we assessed whether the mitochondria targeted antioxidant MitoQ could decrease oxidative damage… CONTINUE READING

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