Protection against lethal enterovirus 71 infection in newborn mice by passive immunization with subunit VP1 vaccines and inactivated virus.

@article{Wu2001ProtectionAL,
  title={Protection against lethal enterovirus 71 infection in newborn mice by passive immunization with subunit VP1 vaccines and inactivated virus.},
  author={C N Wu and Yin C Lin and C H Fann and N S Liao and Shin Ru Shih and Matthew Sai Pong Ho},
  journal={Vaccine},
  year={2001},
  volume={20 5-6},
  pages={895-904}
}
Enterovirus 71 (EV71), the newest member of Enteroviridae, is notable for its etiological role in epidemics of severe neurological diseases in children. Developing effective vaccines is considered a top choice among all control measures. We compared the inactivated virus vaccine (10 microg protein/mouse) with subunit vaccines--VP1 DNA vaccine (100 microg/mouse) or recombinant VP1 protein (10 microg/mouse)--in its ability to elicit maternal antibody and to provide protection against lethal… CONTINUE READING
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