Protection against influenza virus challenge by topical application of influenza DNA vaccine.

@article{Watabe2001ProtectionAI,
  title={Protection against influenza virus challenge by topical application of influenza DNA vaccine.},
  author={Setsuko Watabe and K Q Xin and Atsushi Ihata and Lisa J. Liu and Akiko Honsho and Ichiro Aoki and Kenji Hamajima and Britta E Wahren and Kenji Okuda},
  journal={Vaccine},
  year={2001},
  volume={19 31},
  pages={4434-44}
}
We studied the use of a DNA vaccine expressing the matrix (M) gene of the influenza virus A/PR/8/34. Mice were immunized by painting the DNA vaccine three times on the skin after removal of its keratinocytic layers. Immunization by this method produced M-specific antibodies and cytotoxic T lymphocyte (CTL) response, and acquired resistance against influenza virus challenge. This protection was abrogated by the in vivo injection of anti-CD8 or anti-CD4 monoclonal antibody. We further found that… CONTINUE READING

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