Protection against heterologous human papillomavirus challenge by a synthetic lipopeptide vaccine containing a broadly cross-neutralizing epitope of L2.

@article{Alphs2008ProtectionAH,
  title={Protection against heterologous human papillomavirus challenge by a synthetic lipopeptide vaccine containing a broadly cross-neutralizing epitope of L2.},
  author={Hannah H. Alphs and Ratish Gambhira and Balasubramanyam Karanam and Jeffrey N. Roberts and Subhashini Jagu and John T. Schiller and Weiguang Zeng and David C Jackson and Richard B S Roden},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 15},
  pages={
          5850-5
        }
}
Persistent infection with the high-risk subset of genitotropic human papillomavirus (HPV) genotypes is a necessary cause of cervical cancer. Given the global burden of cervical cancer, a low-cost, broadly protective vaccine is needed. RG-1 is a cross-neutralizing and protective monoclonal antibody that recognizes residues 17-36 of HPV16 minor capsid protein L2. Because this epitope is highly conserved in divergent HPV types, we determined whether vaccination with HPV16 L2 17-36 peptide is… CONTINUE READING

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