Protection against glucose‐induced neuronal death by NAAG and GCP II inhibition is regulated by mGluR3

@article{BerentSpillson2004ProtectionAG,
  title={Protection against glucose‐induced neuronal death by NAAG and GCP II inhibition is regulated by mGluR3},
  author={Alison Berent-Spillson and Amanda M. Robinson and David Golovoy and Barbara S. Slusher and Camilo Rojas and James W. Russell},
  journal={Journal of Neurochemistry},
  year={2004},
  volume={89}
}
Glutamate carboxypeptidase II (GCP II) inhibition has previously been shown to be protective against long‐term neuropathy in diabetic animals. In the current study, we have determined that the GCP II inhibitor 2‐(phosphonomethyl) pentanedioic acid (2‐PMPA) is protective against glucose‐induced programmed cell death (PCD) and neurite degeneration in dorsal root ganglion (DRG) neurons in a cell culture model of diabetic neuropathy. In this model, inhibition of caspase activation is mediated… 

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Selective CNS Uptake of the GCP-II Inhibitor 2-PMPA following Intranasal Administration

Glutamate carboxypeptidase II (GCP-II) is a brain metallopeptidase that hydrolyzes the abundant neuropeptide N-acetyl-aspartyl-glutamate (NAAG) to NAA and glutamate. Small molecule GCP-II inhibitors

Neonatal exposure to MK‐801 reduces mRNA expression of mGlu3 receptors in the medial prefrontal cortex of adolescent rats

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...

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