Protection against dendrotoxin-induced clonic seizures in mice by anticonvulsant drugs.

@article{Coleman1992ProtectionAD,
  title={Protection against dendrotoxin-induced clonic seizures in mice by anticonvulsant drugs.},
  author={Mardia Coleman and Satoshi Yamaguchi and Michael A Rogawski},
  journal={Brain research},
  year={1992},
  volume={575 1},
  pages={138-42}
}
Various anticonvulsant drugs were evaluated for their ability to protect against clonic seizures induced in mice by intraventricular injection of the K+ channel blocking peptide dendrotoxin (DTX). Phenytoin, the phenytoin-like anticonvulsant carbamazepine and the broad spectrum drug valproate were effective in this model, whereas the GABA-enhancers diazepam and tiagabine, the NMDA antagonists (+/-)-CPP and (+)-MK-801, the AMPA antagonist NBQX, the antiabsence drug ethosuximide and the Ca2… CONTINUE READING

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Phenytoin , the phenytoin - like anticonvulsant carbamazepine and the broad spectrum drug valproate were effective in this model , whereas the GABA - enhancers diazepam and tiagabine , the NMDA antagonists ( + /-)-CPP and ( + ) -MK-801 , the AMPA antagonist NBQX , the antiabsence drug ethosuximide and the Ca2 + channel antagonist nimodipine were inactive .
Phenytoin , the phenytoin - like anticonvulsant carbamazepine and the broad spectrum drug valproate were effective in this model , whereas the GABA - enhancers diazepam and tiagabine , the NMDA antagonists ( + /-)-CPP and ( + ) -MK-801 , the AMPA antagonist NBQX , the antiabsence drug ethosuximide and the Ca2 + channel antagonist nimodipine were inactive .
Phenytoin , the phenytoin - like anticonvulsant carbamazepine and the broad spectrum drug valproate were effective in this model , whereas the GABA - enhancers diazepam and tiagabine , the NMDA antagonists ( + /-)-CPP and ( + ) -MK-801 , the AMPA antagonist NBQX , the antiabsence drug ethosuximide and the Ca2 + channel antagonist nimodipine were inactive .
Phenytoin , the phenytoin - like anticonvulsant carbamazepine and the broad spectrum drug valproate were effective in this model , whereas the GABA - enhancers diazepam and tiagabine , the NMDA antagonists ( + /-)-CPP and ( + ) -MK-801 , the AMPA antagonist NBQX , the antiabsence drug ethosuximide and the Ca2 + channel antagonist nimodipine were inactive .
Phenytoin , the phenytoin - like anticonvulsant carbamazepine and the broad spectrum drug valproate were effective in this model , whereas the GABA - enhancers diazepam and tiagabine , the NMDA antagonists ( + /-)-CPP and ( + ) -MK-801 , the AMPA antagonist NBQX , the antiabsence drug ethosuximide and the Ca2 + channel antagonist nimodipine were inactive .
Phenytoin , the phenytoin - like anticonvulsant carbamazepine and the broad spectrum drug valproate were effective in this model , whereas the GABA - enhancers diazepam and tiagabine , the NMDA antagonists ( + /-)-CPP and ( + ) -MK-801 , the AMPA antagonist NBQX , the antiabsence drug ethosuximide and the Ca2 + channel antagonist nimodipine were inactive .
Phenytoin , the phenytoin - like anticonvulsant carbamazepine and the broad spectrum drug valproate were effective in this model , whereas the GABA - enhancers diazepam and tiagabine , the NMDA antagonists ( + /-)-CPP and ( + ) -MK-801 , the AMPA antagonist NBQX , the antiabsence drug ethosuximide and the Ca2 + channel antagonist nimodipine were inactive .
Phenytoin , the phenytoin - like anticonvulsant carbamazepine and the broad spectrum drug valproate were effective in this model , whereas the GABA - enhancers diazepam and tiagabine , the NMDA antagonists ( + /-)-CPP and ( + ) -MK-801 , the AMPA antagonist NBQX , the antiabsence drug ethosuximide and the Ca2 + channel antagonist nimodipine were inactive .
Various anticonvulsant drugs were evaluated for their ability to protect against clonic seizures induced in mice by intraventricular injection of the K+ channel blocking peptide dendrotoxin ( DTX ) .
Protection against dendrotoxin - induced clonic seizures in mice by anticonvulsant drugs .
Phenytoin , the phenytoin - like anticonvulsant carbamazepine and the broad spectrum drug valproate were effective in this model , whereas the GABA - enhancers diazepam and tiagabine , the NMDA antagonists ( + /-)-CPP and ( + ) -MK-801 , the AMPA antagonist NBQX , the antiabsence drug ethosuximide and the Ca2 + channel antagonist nimodipine were inactive .
Phenytoin , the phenytoin - like anticonvulsant carbamazepine and the broad spectrum drug valproate were effective in this model , whereas the GABA - enhancers diazepam and tiagabine , the NMDA antagonists ( + /-)-CPP and ( + ) -MK-801 , the AMPA antagonist NBQX , the antiabsence drug ethosuximide and the Ca2 + channel antagonist nimodipine were inactive .
Phenytoin , the phenytoin - like anticonvulsant carbamazepine and the broad spectrum drug valproate were effective in this model , whereas the GABA - enhancers diazepam and tiagabine , the NMDA antagonists ( + /-)-CPP and ( + ) -MK-801 , the AMPA antagonist NBQX , the antiabsence drug ethosuximide and the Ca2 + channel antagonist nimodipine were inactive .
Phenytoin , the phenytoin - like anticonvulsant carbamazepine and the broad spectrum drug valproate were effective in this model , whereas the GABA - enhancers diazepam and tiagabine , the NMDA antagonists ( + /-)-CPP and ( + ) -MK-801 , the AMPA antagonist NBQX , the antiabsence drug ethosuximide and the Ca2 + channel antagonist nimodipine were inactive .
Phenytoin , the phenytoin - like anticonvulsant carbamazepine and the broad spectrum drug valproate were effective in this model , whereas the GABA - enhancers diazepam and tiagabine , the NMDA antagonists ( + /-)-CPP and ( + ) -MK-801 , the AMPA antagonist NBQX , the antiabsence drug ethosuximide and the Ca2 + channel antagonist nimodipine were inactive .
Phenytoin , the phenytoin - like anticonvulsant carbamazepine and the broad spectrum drug valproate were effective in this model , whereas the GABA - enhancers diazepam and tiagabine , the NMDA antagonists ( + /-)-CPP and ( + ) -MK-801 , the AMPA antagonist NBQX , the antiabsence drug ethosuximide and the Ca2 + channel antagonist nimodipine were inactive .
Phenytoin , the phenytoin - like anticonvulsant carbamazepine and the broad spectrum drug valproate were effective in this model , whereas the GABA - enhancers diazepam and tiagabine , the NMDA antagonists ( + /-)-CPP and ( + ) -MK-801 , the AMPA antagonist NBQX , the antiabsence drug ethosuximide and the Ca2 + channel antagonist nimodipine were inactive .
Phenytoin , the phenytoin - like anticonvulsant carbamazepine and the broad spectrum drug valproate were effective in this model , whereas the GABA - enhancers diazepam and tiagabine , the NMDA antagonists ( + /-)-CPP and ( + ) -MK-801 , the AMPA antagonist NBQX , the antiabsence drug ethosuximide and the Ca2 + channel antagonist nimodipine were inactive .
Phenytoin , the phenytoin - like anticonvulsant carbamazepine and the broad spectrum drug valproate were effective in this model , whereas the GABA - enhancers diazepam and tiagabine , the NMDA antagonists ( + /-)-CPP and ( + ) -MK-801 , the AMPA antagonist NBQX , the antiabsence drug ethosuximide and the Ca2 + channel antagonist nimodipine were inactive .
Phenytoin , the phenytoin - like anticonvulsant carbamazepine and the broad spectrum drug valproate were effective in this model , whereas the GABA - enhancers diazepam and tiagabine , the NMDA antagonists ( + /-)-CPP and ( + ) -MK-801 , the AMPA antagonist NBQX , the antiabsence drug ethosuximide and the Ca2 + channel antagonist nimodipine were inactive .
Phenytoin , the phenytoin - like anticonvulsant carbamazepine and the broad spectrum drug valproate were effective in this model , whereas the GABA - enhancers diazepam and tiagabine , the NMDA antagonists ( + /-)-CPP and ( + ) -MK-801 , the AMPA antagonist NBQX , the antiabsence drug ethosuximide and the Ca2 + channel antagonist nimodipine were inactive .
Phenytoin , the phenytoin - like anticonvulsant carbamazepine and the broad spectrum drug valproate were effective in this model , whereas the GABA - enhancers diazepam and tiagabine , the NMDA antagonists ( + /-)-CPP and ( + ) -MK-801 , the AMPA antagonist NBQX , the antiabsence drug ethosuximide and the Ca2 + channel antagonist nimodipine were inactive .
Phenytoin , the phenytoin - like anticonvulsant carbamazepine and the broad spectrum drug valproate were effective in this model , whereas the GABA - enhancers diazepam and tiagabine , the NMDA antagonists ( + /-)-CPP and ( + ) -MK-801 , the AMPA antagonist NBQX , the antiabsence drug ethosuximide and the Ca2 + channel antagonist nimodipine were inactive .
Phenytoin , the phenytoin - like anticonvulsant carbamazepine and the broad spectrum drug valproate were effective in this model , whereas the GABA - enhancers diazepam and tiagabine , the NMDA antagonists ( + /-)-CPP and ( + ) -MK-801 , the AMPA antagonist NBQX , the antiabsence drug ethosuximide and the Ca2 + channel antagonist nimodipine were inactive .
Phenytoin , the phenytoin - like anticonvulsant carbamazepine and the broad spectrum drug valproate were effective in this model , whereas the GABA - enhancers diazepam and tiagabine , the NMDA antagonists ( + /-)-CPP and ( + ) -MK-801 , the AMPA antagonist NBQX , the antiabsence drug ethosuximide and the Ca2 + channel antagonist nimodipine were inactive .
Phenytoin , the phenytoin - like anticonvulsant carbamazepine and the broad spectrum drug valproate were effective in this model , whereas the GABA - enhancers diazepam and tiagabine , the NMDA antagonists ( + /-)-CPP and ( + ) -MK-801 , the AMPA antagonist NBQX , the antiabsence drug ethosuximide and the Ca2 + channel antagonist nimodipine were inactive .
Phenytoin , the phenytoin - like anticonvulsant carbamazepine and the broad spectrum drug valproate were effective in this model , whereas the GABA - enhancers diazepam and tiagabine , the NMDA antagonists ( + /-)-CPP and ( + ) -MK-801 , the AMPA antagonist NBQX , the antiabsence drug ethosuximide and the Ca2 + channel antagonist nimodipine were inactive .
Phenytoin , the phenytoin - like anticonvulsant carbamazepine and the broad spectrum drug valproate were effective in this model , whereas the GABA - enhancers diazepam and tiagabine , the NMDA antagonists ( + /-)-CPP and ( + ) -MK-801 , the AMPA antagonist NBQX , the antiabsence drug ethosuximide and the Ca2 + channel antagonist nimodipine were inactive .
Phenytoin , the phenytoin - like anticonvulsant carbamazepine and the broad spectrum drug valproate were effective in this model , whereas the GABA - enhancers diazepam and tiagabine , the NMDA antagonists ( + /-)-CPP and ( + ) -MK-801 , the AMPA antagonist NBQX , the antiabsence drug ethosuximide and the Ca2 + channel antagonist nimodipine were inactive .
Phenytoin , the phenytoin - like anticonvulsant carbamazepine and the broad spectrum drug valproate were effective in this model , whereas the GABA - enhancers diazepam and tiagabine , the NMDA antagonists ( + /-)-CPP and ( + ) -MK-801 , the AMPA antagonist NBQX , the antiabsence drug ethosuximide and the Ca2 + channel antagonist nimodipine were inactive .
Protection against dendrotoxin - induced clonic seizures in mice by anticonvulsant drugs .
Various anticonvulsant drugs were evaluated for their ability to protect against clonic seizures induced in mice by intraventricular injection of the K+ channel blocking peptide dendrotoxin ( DTX ) .
Phenytoin , the phenytoin - like anticonvulsant carbamazepine and the broad spectrum drug valproate were effective in this model , whereas the GABA - enhancers diazepam and tiagabine , the NMDA antagonists ( + /-)-CPP and ( + ) -MK-801 , the AMPA antagonist NBQX , the antiabsence drug ethosuximide and the Ca2 + channel antagonist nimodipine were inactive .
Phenytoin , the phenytoin - like anticonvulsant carbamazepine and the broad spectrum drug valproate were effective in this model , whereas the GABA - enhancers diazepam and tiagabine , the NMDA antagonists ( + /-)-CPP and ( + ) -MK-801 , the AMPA antagonist NBQX , the antiabsence drug ethosuximide and the Ca2 + channel antagonist nimodipine were inactive .
Phenytoin , the phenytoin - like anticonvulsant carbamazepine and the broad spectrum drug valproate were effective in this model , whereas the GABA - enhancers diazepam and tiagabine , the NMDA antagonists ( + /-)-CPP and ( + ) -MK-801 , the AMPA antagonist NBQX , the antiabsence drug ethosuximide and the Ca2 + channel antagonist nimodipine were inactive .
Phenytoin , the phenytoin - like anticonvulsant carbamazepine and the broad spectrum drug valproate were effective in this model , whereas the GABA - enhancers diazepam and tiagabine , the NMDA antagonists ( + /-)-CPP and ( + ) -MK-801 , the AMPA antagonist NBQX , the antiabsence drug ethosuximide and the Ca2 + channel antagonist nimodipine were inactive .
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