Protection against Respiratory Syncytial Virus Infection by DNA Immunization

@article{Li1998ProtectionAR,
  title={Protection against Respiratory Syncytial Virus Infection by DNA Immunization },
  author={Xiaomao Li and Suryaprakash Sambhara and Cindy Xin Li and Mary E. Ewasyshyn and Mark Parrington and Judy Caterini and Olive James and George Cates and Run-Pan Du and Michel C. A. Klein},
  journal={The Journal of Experimental Medicine},
  year={1998},
  volume={188},
  pages={681 - 688}
}
Respiratory syncytial virus (RSV) remains a major cause of morbidity and mortality in infants and the elderly and is a continuing challenge for vaccine development. A murine T helper cell (Th) type 2 response associates with enhanced lung pathology, which has been observed in past infant trials using formalin-inactivated RSV vaccine. In this study, we have engineered an optimized plasmid DNA vector expressing the RSV fusion (F) protein (DNA-F). DNA-F was as effective as live RSV in mice at… CONTINUE READING
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