Protection against Plasmodium falciparum malaria by PfSPZ Vaccine.

  title={Protection against Plasmodium falciparum malaria by PfSPZ Vaccine.},
  author={Judith E. Epstein and Kristopher M. Paolino and Thomas L. Richie and Martha Sedegah and Alexandra Singer and Adam J. Ruben and Sumana Chakravarty and April Stafford and Richard C. Ruck and Abraham G. Eappen and Tao Li and Peter F. Billingsley and Anita Manoj and Joana C. Silva and Kara A. Moser and Robin K Nielsen and Donna Tosh and Susan Cicatelli and Harini D. Ganeshan and Jessica Case and Debbie Padilla and Silas A. Davidson and Lindsey S Garver and Elizabeth Saverino and Tooba Murshedkar and A. Viran Gunasekera and Patrick S Twomey and Sharina M Reyes and James E. Moon and Eric R. James and Natasha Kc and Minglin Li and Esteban N. Abot and Arnel Belmonte and Kevin Hauns and Maria N. Belmonte and Jun Huang and Carlos S Vasquez and Shon A. Remich and Mary N Carrington and Yonas Abebe and Amy Tillman and Bradley W. Hickey and Jason A. Regules and Eileen Franke Villasante and Betty Kim Lee Sim and Stephen L Hoffman},
  journal={JCI insight},
  volume={2 1},
BACKGROUND: A radiation-attenuated Plasmodium falciparum (Pf) sporozoite (SPZ) malaria vaccine, PfSPZ Vaccine, protected 6 of 6 subjects (100%) against homologous Pf (same strain as in the vaccine) controlled human malaria infection (CHMI) 3 weeks after 5 doses administered intravenously. The next step was to assess protective efficacy against heterologous Pf (different from Pf in the vaccine), after fewer doses, and at 24 weeks. METHODS: The trial assessed tolerability, safety, immunogenicity… CONTINUE READING


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Publications referenced by this paper.
Showing 1-10 of 32 references

Genetic analysis of the human malaria parasite

D Walliker
Plasmodium falciparum. Science • 1987
View 4 Excerpts
Highly Influenced

A British Airways flight attendant has died of malaria after a long-haul flight to Africa. Daily Mirror. http:// 1 4

S. Hayward
Published July • 2015
View 1 Excerpt

Genetic Diversity and Protective Efficacy of the RTS,S/AS01 Malaria Vaccine

DE Neafsey
N Engl J Med • 2015

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