Protection against Myocardial Ischemia-Reperfusion Injury at Onset of Type 2 Diabetes in Zucker Diabetic Fatty Rats Is Associated with Altered Glucose Oxidation

@inproceedings{Povlsen2013ProtectionAM,
  title={Protection against Myocardial Ischemia-Reperfusion Injury at Onset of Type 2 Diabetes in Zucker Diabetic Fatty Rats Is Associated with Altered Glucose Oxidation},
  author={Jonas Agerlund Povlsen and B L{\o}fgren and Christian Warnke Dalgas and Rune Isak Dupont Birkler and Mogens Johannsen and Nicolaj Brejnholt St{\o}ttrup and Hans Erik B{\o}tker},
  booktitle={PloS one},
  year={2013}
}
BACKGROUND Inhibition of glucose oxidation during initial reperfusion confers protection against ischemia-reperfusion (IR) injury in the heart. Mitochondrial metabolism is altered with progression of type 2 diabetes (T2DM). We hypothesized that the metabolic alterations present at onset of T2DM induce cardioprotection by metabolic shutdown during IR, and that chronic alterations seen in late T2DM cause increased IR injury. METHODS Isolated perfused hearts from 6 (prediabetic), 12 (onset of… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 60 REFERENCES

Preconditioning protects the heart in a prolonged uremic condition.

  • American journal of physiology. Heart and circulatory physiology
  • 2012
VIEW 1 EXCERPT

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