Protection against Multiple Influenza A Virus Strains Induced by Candidate Recombinant Vaccine Based on Heterologous M2e Peptides Linked to Flagellin

@inproceedings{Stepanova2015ProtectionAM,
  title={Protection against Multiple Influenza A Virus Strains Induced by Candidate Recombinant Vaccine Based on Heterologous M2e Peptides Linked to Flagellin},
  author={Liudmila A Stepanova and Roman Y Kotlyarov and Anna Kovaleva and Marina V. Potapchuk and Alexandr V. Korotkov and Mariia V. Sergeeva and Marina A. Kasianenko and Victor V. Kuprianov and Nikolai V. Ravin and Liudmila M Tsybalova and Konstantin G. Skryabin and Oleg I. Kiselev},
  booktitle={PloS one},
  year={2015}
}
Matrix 2 protein ectodomain (M2e) is considered a promising candidate for a broadly protective influenza vaccine. M2e-based vaccines against human influenza A provide only partial protection against avian influenza viruses because of differences in the M2e sequences. In this work, we evaluated the possibility of obtaining equal protection and immune response by using recombinant protein on the basis of flagellin as a carrier of the M2e peptides of human and avian influenza A viruses… CONTINUE READING
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