Protection against Mucosal SHIV Challenge by Peptide and Helper-Dependent Adenovirus Vaccines

  title={Protection against Mucosal SHIV Challenge by Peptide and Helper-Dependent Adenovirus Vaccines},
  author={Eric A. Weaver and Pramod N Nehete and Bharti P. Nehete and Stephanie J. Buchl and Donna J. Palmer and David C. Montefiori and Philip Ng and K Jagannadha Sastry and Michael Anthony Barry},
Groups of rhesus macaques that had previously been immunized with HIV-1 envelope (env) peptides and first generation adenovirus serotype 5 (FG-Ad5) vaccines expressing the same peptides were immunized intramuscularly three times with helper-dependent adenovirus (HD-Ad) vaccines expressing only the HIV-1 envelope from JRFL. No gag, pol, or other SHIV genes were used for vaccination. One group of the FG-Ad5-immune animals was immunized three times with HD-Ad5 expressing env. One group was… CONTINUE READING
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