Protection against Gluten-mediated Tight Junction Injury with a NovelLignite Extract Supplement

  title={Protection against Gluten-mediated Tight Junction Injury with a NovelLignite Extract Supplement},
  author={John J. Gildea and David A. Roberts and Zachary D. Bush},
  journal={Journal of Nutrition and Food Sciences},
Background: Tight junctions are found in epithelial cells and function as selective gatekeepers to regulate absorption. PT-gliadin is the gluten protein segment that is known to impair the functioning of tight junctions. This study aimed to examine the effects of a lignite extract dietary supplement (RESTORE) on tight junction function in small intestine (IEC-6) and colon (Caco-2) epithelial cells. The study also evaluated the biologic safety of the same supplement as established by the rates… 
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