Protection against Fas/APO-1- and tumor necrosis factor-mediated cell death by a novel protein, sentrin.

@article{Okura1996ProtectionAF,
  title={Protection against Fas/APO-1- and tumor necrosis factor-mediated cell death by a novel protein, sentrin.},
  author={Takashi Okura and Lili Gong and Tetsu Kamitani and Teiji Wada and Ichiro Okura and Chik Fong Wei and Heung Moon Chang and Edward T. H. Yeh},
  journal={Journal of immunology},
  year={1996},
  volume={157 10},
  pages={4277-81}
}
Fas/APO-1 and TNF receptor 1 share a common signaling motif in their cytoplasmic tail called the "death domain." Using the death domain as bait in the yeast two-hybrid system, several death domain-containing proteins that participate in cell death signaling have been identified. Here we report the isolation of a novel protein, sentrin, which interacts with Fas/APO-1 and TNF receptor 1 but not with FADD/MORT1 or CD40. Two-hybrid interaction assays reveal that sentrin associates only with the… CONTINUE READING

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