Protection against Cisplatin-Induced Toxicities by N-Acetylcysteine and Sodium Thiosulfate as Assessed at the Molecular, Cellular, and in Vivo Levels

  title={Protection against Cisplatin-Induced Toxicities by N-Acetylcysteine and Sodium Thiosulfate as Assessed at the Molecular, Cellular, and in Vivo Levels},
  author={D. Dickey and Y. Wu and L. Muldoon and E. Neuwelt},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  pages={1052 - 1058}
  • D. Dickey, Y. Wu, +1 author E. Neuwelt
  • Published 2005
  • Medicine
  • Journal of Pharmacology and Experimental Therapeutics
  • Cisplatin (CDDP) is a common, highly toxic chemotherapeutic agent. This study investigates chemoprotective effects of N-acetylcysteine (NAC) and sodium thiosulfate (STS) on in vitro and in vivo CDDP toxicities. For ototoxicity studies, CDDP (6 mg/kg) was administered to rats via a retrograde carotid artery infusion. Auditory brainstem response thresholds at 4 to 20 kHz were tested before and 7 days post-treatment. STS (8 g/m2 i.v.) was administered at 4, 8, or 12 h after CDDP. For… CONTINUE READING
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