Protection against Cisplatin-Induced Toxicities by N-Acetylcysteine and Sodium Thiosulfate as Assessed at the Molecular, Cellular, and in Vivo Levels

@article{Dickey2005ProtectionAC,
  title={Protection against Cisplatin-Induced Toxicities by N-Acetylcysteine and Sodium Thiosulfate as Assessed at the Molecular, Cellular, and in Vivo Levels},
  author={D. Dickey and Y. Wu and L. Muldoon and E. Neuwelt},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  year={2005},
  volume={314},
  pages={1052 - 1058}
}
  • D. Dickey, Y. Wu, +1 author E. Neuwelt
  • Published 2005
  • Medicine
  • Journal of Pharmacology and Experimental Therapeutics
    • Cisplatin (CDDP) is a common, highly toxic chemotherapeutic agent. This study investigates chemoprotective effects of N-acetylcysteine (NAC) and sodium thiosulfate (STS) on in vitro and in vivo CDDP toxicities. For ototoxicity studies, CDDP (6 mg/kg) was administered to rats via a retrograde carotid artery infusion. Auditory brainstem response thresholds at 4 to 20 kHz were tested before and 7 days post-treatment. STS (8 g/m2 i.v.) was administered at 4, 8, or 12 h after CDDP. For… CONTINUE READING
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    References

    SHOWING 1-10 OF 37 REFERENCES
    Protection against cisplatin-induced ototoxicity by N-acetylcysteine in a rat model
    • 111
    Delayed administration of sodium thiosulfate in animal models reduces platinum ototoxicity without reduction of antitumor activity.
    • L. Muldoon, M. Pagel, +5 authors E. Neuwelt
    • Medicine
    • Clinical cancer research : an official journal of the American Association for Cancer Research
    • 2000
    • 110
    • PDF
    d-Methionine provides excellent protection from cisplatin ototoxicity in the rat
    • 222
    Therapeutic efficacy of aortic administration of N-acetylcysteine as a chemoprotectant against bone marrow toxicity after intracarotid administration of alkylators, with or without glutathione depletion in a rat model.
    • 61
    • PDF
    The comparative effects of sodium thiosulfate, diethyldithiocarbamate, fosfomycin and WR-2721 on ameliorating cisplatin-induced ototoxicity
    • 82
    In vitro and animal studies of sodium thiosulfate as a potential chemoprotectant against carboplatin-induced ototoxicity.
    • 48
    • PDF
    Bone Marrow Chemoprotection without Compromise of Chemotherapy Efficacy in a Rat Brain Tumor Model
    • 59
    • PDF
    The Chemoprotective Agent N-Acetylcysteine Blocks Cisplatin-Induced Apoptosis through Caspase Signaling Pathway
    • 166
    • PDF
    Tiopronin protects against the nephrotoxicity of cisplatin in the rat
    • 18
    Cisplatin nephrotoxicity: site of functional disturbance and correlation to loss of body weight.
    • 19