Protection against Acetaldehyde Toxicity in the rat byl-cysteine, thiamin andl-2-Methylthiazolidine-4-carboxylic acid

  title={Protection against Acetaldehyde Toxicity in the rat byl-cysteine, thiamin andl-2-Methylthiazolidine-4-carboxylic acid},
  author={H. Sprince and C. Parker and G. G. Smith and Leon J. Gonzales},
  journal={Agents and Actions},
  • H. Sprince, C. Parker, +1 author Leon J. Gonzales
  • Published 2005
  • Chemistry, Medicine
  • Agents and Actions
  • Acetaldehyde is 10–30 times more toxic than ethanol and has been implicated in alcoholic cardiomyopathy. Its oral LD50 and LD90 Litchfield-Wilcoxon values were found to be 15.0 (14.4–15.6) mM/kg and 18.0 (15.5–20.5) mM/kg, respectively. Protection against acetaldehyde lethality was obtained by oral intubation of test compounds 30–45 minutes prior to oral intubation of 18 mM/kg of acetaldehyde. At 2.0 mM/kg, survival after 24–72 hours withl-cysteine free base(FB)was80%;withl-2-methylthiazolidine… CONTINUE READING
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