Protection Against Photoaging in the Hairless Mouse by the Isoflavone Equol

@inproceedings{Reeve2005ProtectionAP,
  title={Protection Against Photoaging in the Hairless Mouse by the Isoflavone Equol},
  author={Vivienne E. Reeve and Sitarina Widyarini and Diane Domanski and E. Chew and Karen Barnes},
  booktitle={Photochemistry and photobiology},
  year={2005}
}
Abstract Topical application of the isoflavone equol immediately following solar-simulated UV (SSUV) radiation exposure has previously been demonstrated to have significant photoprotective effects. Equol reduced both the inflammatory edema and the systemic suppression of the contact hypersensitivity reaction in hairless mice. Furthermore, daily topical equol application immediately following irradiation during a 10-week chronic SSUV exposure regime also reduced photocarcinogenesis severity in… 
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TLDR
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Protective Effect of the Isoflavonoid Equol Against Hairless Mouse Skin Carcinogenesis Induced by UV Radiation Alone or with a Chemical Cocarcinogen¶
TLDR
In a short-term study, equol dose dependently inhibited the SSUV induction of the tumor promotion biomarker enzyme, ornithine decarboxylase, in the skin, suggesting the anticarcinogenic activity of equol may be attributed to its inhibition of the tumors promotion phase of carcinogenesis.
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