Protection Against Irreversible Hemorrhagic Shock by Allopurinol

  title={Protection Against Irreversible Hemorrhagic Shock by Allopurinol},
  author={Carleton H. Baker},
  journal={Proceedings of the Society for Experimental Biology and Medicine},
  pages={694 - 698}
Summary The xanthine oxidase inhibitor allopurinol alone or in combination with hypoxanthine and adenine exerted little or no protection against the onset of irreversible shock. However when allopurinol is combined with the above two compounds in addition to inosine, alpha-ketoglutarate and oxalacetate 48 hr survival was increased to 43%. This may be due to prevention of loss of purine bases as well as supply of compounds to stimulate high-energy phosphate production. The effects may also be… CONTINUE READING


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