Protectin DX increases survival in a mouse model of sepsis by ameliorating inflammation and modulating macrophage phenotype

Abstract

Recently, a serial of studies have demonstrated that lipid mediators derived from Omega-3 fatty acid docosahexaenoic acid have pro-resolving or anti-inflammatory effects in many inflammatory diseases. Here, we sought to evaluate whether Protectin DX (PDX, an isomer of Protecin D1), a newly identified lipid mediator, could protect mice against sepsis and… (More)
DOI: 10.1038/s41598-017-00103-0

Topics

8 Figures and Tables

Cite this paper

@inproceedings{Xia2017ProtectinDI, title={Protectin DX increases survival in a mouse model of sepsis by ameliorating inflammation and modulating macrophage phenotype}, author={Haifa Xia and Lin Chen and Hong Liu and Zhipeng Sun and Wen Yang and Yiyi Yang and Shunan Cui and Shengnan Li and Yaxin Wang and Limin Song and Amro Fayez Abdelgawad and You Lin Shang and Shang-long Yao}, booktitle={Scientific reports}, year={2017} }