Protected hinge in the immunoglobulin G2-A2 disulfide isoform.

@article{Liu2014ProtectedHI,
  title={Protected hinge in the immunoglobulin G2-A2 disulfide isoform.},
  author={Yaoqing Diana Liu and Robert Y-T Chou and Thomas M. Dillon and Leszek Poppe and Christopher S Spahr and Stone D-H Shi and Gregory C. Flynn},
  journal={Protein science : a publication of the Protein Society},
  year={2014},
  volume={23 12},
  pages={1753-64}
}
Human IgG2 consists of disulfide-mediated structural isoforms, classified by the number of Fab arms disulfide-linked to the heavy chain hinge. In the IgG2-B isoform, both Fab arms are linked to the hinge region, and in IgG2-A, neither Fab arm are linked to the hinge. IgG2-A/B is a hybrid between these two forms, with only one Fab arm disulfide-linked to the hinge. Within each of these isoform types are subtypes, with subtle disulfide-linkage differences. Here we explored the structural basis… CONTINUE READING

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In the IgG2-B isoform , both Fab arms are linked to the hinge region , and in IgG2-A , neither Fab arm are linked to the hinge .
In the IgG2-B isoform , both Fab arms are linked to the hinge region , and in IgG2-A , neither Fab arm are linked to the hinge .
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