Protected environments allow parallel evolution of a bacterial pathogen in a patient subjected to long-term antibiotic therapy.

@article{Low2001ProtectedEA,
  title={Protected environments allow parallel evolution of a bacterial pathogen in a patient subjected to long-term antibiotic therapy.},
  author={Angela M S Low and Fiona Marjorie Mackenzie and Ian Malcolm Gould and Ian R. Booth},
  journal={Molecular microbiology},
  year={2001},
  volume={42 3},
  pages={
          619-30
        }
}
Long-term antibiotic treatment offers a rare opportunity to study the evolution of bacteria within the same individual. The appearance of new variants has been suggested to take place via the selection of enhanced resistance in compartments of the body in which the antibiotic concentration is low. Laboratory models of protected compartments have elegantly demonstrated their potential in selecting novel variants. However, comparable data from patients have been rare. In this study, extended… CONTINUE READING
Highly Cited
This paper has 36 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 18 extracted citations