Proteasomes cleave at multiple sites within polyglutamine tracts: activation by PA28gamma(K188E).

@article{Pratt2008ProteasomesCA,
  title={Proteasomes cleave at multiple sites within polyglutamine tracts: activation by PA28gamma(K188E).},
  author={Gregory F. Pratt and Martin Rechsteiner},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 19},
  pages={
          12919-25
        }
}
Eukaryotic proteasomes have been reported to cleave only once within polyglutamine tracts and then only after the N-terminal glutamine (Venkatraman, P., Wetzel, R., Tanaka, M., Nukina, N., and Goldberg, A. L. (2004) Mol. Cell 14, 95-104). We have obtained results that directly conflict with that report. In the presence of the proteasome activator PA28gamma(K188E) human red cell proteasomes progressively degraded fluorescein-GGQ(10)RR or fluorescein-HPHQ(10)RR into small fragments as shown by… CONTINUE READING
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