Proteasomes and their associated ATPases: a destructive combination.

@article{Smith2006ProteasomesAT,
  title={Proteasomes and their associated ATPases: a destructive combination.},
  author={Davey M. Smith and Nadia Benaroudj and Alfred L Goldberg},
  journal={Journal of structural biology},
  year={2006},
  volume={156 1},
  pages={72-83}
}
Protein degradation by 20S proteasomes in vivo requires ATP hydrolysis by associated hexameric AAA ATPase complexes such as PAN in archaea and the homologous ATPases in the eukaryotic 26S proteasome. This review discusses recent insights into their multistep mechanisms and the roles of ATP. We have focused on the PAN complex, which offers many advantages for mechanistic and structural studies over the more complex 26S proteasome. By single-particle EM, PAN resembles a "top-hat" capping the ends… CONTINUE READING

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