Proteasomes: Isolation and Activity Assays.

Abstract

In eukaryotes, damaged or unneeded proteins are typically degraded by the ubiquitin-proteasome system. In this system, the protein substrate is often first covalently modified with a chain of ubiquitin polypeptides. This chain serves as a signal for delivery to the 26S proteasome, a 2.5-MDa, ATP-dependent multisubunit protease complex. The proteasome… (More)
DOI: 10.1002/0471143030.cb0343s67

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Cite this paper

@article{Li2015ProteasomesIA, title={Proteasomes: Isolation and Activity Assays.}, author={YanJie Li and Robert J. Tomko and Mark Hochstrasser}, journal={Current protocols in cell biology}, year={2015}, volume={67}, pages={3.43.1-20} }