Proteasomes: destruction as a programme.

@article{Hilt1996ProteasomesDA,
  title={Proteasomes: destruction as a programme.},
  author={Wolfgang Hilt and Dieter Heinrich Wolf},
  journal={Trends in biochemical sciences},
  year={1996},
  volume={21 3},
  pages={
          96-102
        }
}
Proteasomes are large multi-subunit protease complexes that selectively degrade intracellular proteins. Most of the proteins removed by these proteases are tagged for destruction by ubiquitination. Proteasomes have a role to play in controlling cellular processes, such as metabolism and the cell cycle, through signal-mediated proteolysis of key enzymes and regulatory proteins. They also operate in the stress response, by removing abnormal proteins, and in the immune response, by generating… CONTINUE READING

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