Proteasome regulation of ULBP1 transcription.

  title={Proteasome regulation of ULBP1 transcription.},
  author={James E Butler and Mikel B. Moore and Steven R. Presnell and H Chan and N. Jan Chalupny and Charles T. Lutz},
  journal={Journal of immunology},
  volume={182 10},
Killer lymphocytes recognize stress-activated NKG2D ligands on tumors. We examined NKG2D ligand expression in head and neck squamous cell carcinoma (HNSCC) cells and other cell lines. HNSCC cells typically expressed MHC class I chain-related gene A (MICA), MICB, UL16-binding protein (ULBP)2, and ULBP3, but they were uniformly negative for cell surface ULBP1 and ULBP4. We then studied how cancer treatments affected NKG2D ligand expression. NKG2D ligand expression was not changed by most cancer… CONTINUE READING


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