Proteasome mediates dopaminergic neuronal degeneration, and its inhibition causes alpha-synuclein inclusions.

@article{Sawada2004ProteasomeMD,
  title={Proteasome mediates dopaminergic neuronal degeneration, and its inhibition causes alpha-synuclein inclusions.},
  author={Hideyuki Sawada and Ryuichi Kohno and Takeshi Kihara and Yasuhiko Izumi and Noriko Sakka and Masakazu Ibi and Miki Nakanishi and Tomoki Nakamizo and Kentarou Yamakawa and Hiroshi Shibasaki and Noriyuki Yamamoto and Akinori Akaike and Masatoshi Inden and Yoshihisa Kitamura and Takashi Taniguchi and Shun Shimohama},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 11},
  pages={10710-9}
}
Parkinson's disease is characterized by dopaminergic neuronal death and the presence of Lewy bodies. alpha-Synuclein is a major component of Lewy bodies, but the process of its accumulation and its relationship to dopaminergic neuronal death has not been resolved. Although the pathogenesis has not been clarified, mitochondrial complex I is suppressed, and caspase-3 is activated in the affected midbrain. Here we report that a combination of 1-methyl-4-phenylpyridinium ion (MPP(+)) or rotenone… CONTINUE READING
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