Proteasome-mediated degradation of Rac1-GTP during epithelial cell scattering.

  title={Proteasome-mediated degradation of Rac1-GTP during epithelial cell scattering.},
  author={Emma A Lynch and Jennifer N Stall and Gudila Schmidt and Philippe Chavrier and Crislyn D'Souza-Schorey},
  journal={Molecular biology of the cell},
  volume={17 5},
Epithelial cells disassemble their adherens junctions and "scatter" during processes such as tumor cell invasion as well as some stages of embryonic development. Control of actin polymerization is a powerful mechanism for regulating the strength of cell-cell adhesion. In this regard, studies have shown that sustained activation of Rac1, a well-known regulator of actin dynamics, results in the accumulation of polymerized actin at cell-cell contacts in epithelia and an increase in E-cadherin… CONTINUE READING


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signals at adherens junctions

  • M. Pop, K. Aktories, G. Schmidt
  • 2004
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