Proteasome inhibitors uncouple rhesus TRIM5alpha restriction of HIV-1 reverse transcription and infection.

@article{Wu2006ProteasomeIU,
  title={Proteasome inhibitors uncouple rhesus TRIM5alpha restriction of HIV-1 reverse transcription and infection.},
  author={Xiaolu Wu and Jenny Louise Anderson and Edward M. Campbell and Ajith Mathew Joseph and Thomas J Hope},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 19},
  pages={7465-70}
}
The primate TRIM5alpha proteins have recently been defined as cellular restriction factors, preventing primate infection by retroviruses from different species. For instance, rhesus TRIM5alpha (rhTRIM5alpha) restricts infection by HIV-1. Virtually all TRIM5alpha proteins block the early replication of retroviruses by preventing the accumulation of reverse transcription products, but the underlying mechanism remains unclear. In this article, we find that disrupting proteasome function alters… CONTINUE READING

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