Proteasome inhibitors induce intracellular protein aggregation and cell death by an oxygen-dependent mechanism.

@article{Demasi2003ProteasomeII,
  title={Proteasome inhibitors induce intracellular protein aggregation and cell death by an oxygen-dependent mechanism.},
  author={Marilene Demasi and Kelvin J A Davies},
  journal={FEBS letters},
  year={2003},
  volume={542 1-3},
  pages={89-94}
}
Clone 9 liver cells incubated under aerobic conditions with the proteasome inhibitors lactacystin, clastro lactacystin beta-lactone, and tri-leucine vinyl sulfone, in the absence of an obvious oxidative challenge, underwent oxidative protein modifications, such as loss of solubility, formation of aggregates (predominantly by disulfide bridges), and increased carbonyl formation, similar to those seen with hydrogen peroxide treatment. These alterations were accompanied by modification of cell… CONTINUE READING

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