Proteasome inhibitors block development of Plasmodium spp.

  title={Proteasome inhibitors block development of Plasmodium spp.},
  author={S M Gantt and Joon Mo Myung and Marcelo R. S. Briones and Weikang Li and E. J. Corey and Satoshi O̅mura and Victor Nussenzweig and Photini Sinnis},
  journal={Antimicrobial agents and chemotherapy},
  volume={42 10},
Proteasomes degrade most of the proteins inside eukaryotic cells, including transcription factors and regulators of cell cycle progression. Here we show that nanomolar concentrations of lactacystin, a specific irreversible inhibitor of the 20S proteasome, inhibit development of the exoerythrocytic and erythrocytic stages of the malaria parasite. Although lactacystin-treated Plasmodium berghei sporozoites are still invasive, their development into exoerythrocytic forms (EEF) is inhibited in… CONTINUE READING
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