Proteasome inhibitors block a late step in lysosomal transport of selected membrane but not soluble proteins.

@article{Kerkhof2001ProteasomeIB,
  title={Proteasome inhibitors block a late step in lysosomal transport of selected membrane but not soluble proteins.},
  author={Peter van Kerkhof and C M Alves dos Santos and Martin Sachse and Judith Klumperman and Guojun Bu and Ger J. A. M. Strous},
  journal={Molecular biology of the cell},
  year={2001},
  volume={12 8},
  pages={
          2556-66
        }
}
The ubiquitin-proteasome pathway acts as a regulator of the endocytosis of selected membrane proteins. Recent evidence suggests that it may also function in the intracellular trafficking of membrane proteins. In this study, several models were used to address the role of the ubiquitin-proteasome pathway in sorting of internalized proteins to the lysosome. We found that lysosomal degradation of ligands, which remain bound to their receptors within the endocytic pathway, is blocked in the… CONTINUE READING

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