Proteasome inhibitors block HIV-1 replication by affecting both cellular and viral targets.

@article{Yu2009ProteasomeIB,
  title={Proteasome inhibitors block HIV-1 replication by affecting both cellular and viral targets.},
  author={Liang Yu and Venkatramanan Mohanram and Oscar E. Simonson and C I Edvard Smith and Anna-Lena Spetz and Abdalla J. Mohamed},
  journal={Biochemical and biophysical research communications},
  year={2009},
  volume={385 1},
  pages={100-5}
}
HIV-1 has proved to be notoriously difficult to tackle despite the availability of more than 20 clinically approved drugs. The majority of these drugs, however, target viral genes and their continued use will select for drug-resistant strains. Since NF-kappaB signaling is critical for viral replication, we wanted to investigate the effect of proteasome inhibitors on viral gene expression. We herein demonstrate that proteasome and NF-kappaB inhibitors effectively shut down transcription from the… CONTINUE READING