Proteasome inhibitors: recent advances and new perspectives in medicinal chemistry.

@article{Genin2010ProteasomeIR,
  title={Proteasome inhibitors: recent advances and new perspectives in medicinal chemistry.},
  author={Emilie Genin and Mich{\`e}le Reboud-Ravaux and Jeremy Vidal},
  journal={Current topics in medicinal chemistry},
  year={2010},
  volume={10 3},
  pages={
          232-56
        }
}
The search for proteasome inhibitors began fifteen years ago. These inhibitors proved to be powerful tools for investigating many important cellular processes regulated by the ubiquitin-proteasome pathway. Targeting the proteasome pathway can also lead to new treatments for disorders like cancer, muscular dystrophies, inflammation and immune diseases. This is already true for cancer; the FDA approved bortezomib, a potent proteasome inhibitor, for treating multiple myeloma in 2003, and mantle… CONTINUE READING
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