Proteasome inhibitor induces apoptosis through induction of endoplasmic reticulum stress.

@article{Fribley2006ProteasomeII,
  title={Proteasome inhibitor induces apoptosis through induction of endoplasmic reticulum stress.},
  author={Andrew M. Fribley and Cun-yu Wang},
  journal={Cancer biology & therapy},
  year={2006},
  volume={5 7},
  pages={745-8}
}
The 26S proteasome is a large multi-subunit protein complex found in the cytoplasm and nucleus of mammalian cells which plays a critical role in intracellular proteolysis. It has been found that the 26S proteasome degrades multiple important substrates which are associated with tumor growth and development. Emerging evidence demonstrates that proteasome inhibition is an innovative and effective approach for treating some human cancers. PS-341 (also known as Velcade or Bortezomib), a specific… CONTINUE READING

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