Proteasome inhibitor PS-341 induces growth arrest and apoptosis of non-small cell lung cancer cells via the JNK/c-Jun/AP-1 signaling.

@article{Yang2004ProteasomeIP,
  title={Proteasome inhibitor PS-341 induces growth arrest and apoptosis of non-small cell lung cancer cells via the JNK/c-Jun/AP-1 signaling.},
  author={Yang Yang and Takeyuki Ikezoe and Tsuyako Saito and Makoto Kobayashi and H Phillip Koeffler and Hirokuni Taguchi},
  journal={Cancer science},
  year={2004},
  volume={95 2},
  pages={176-80}
}
Proteasome inhibitor PS-341 induces growth arrest and apoptosis of multiple myeloma (MM) cells via inactivation of NF-kappaB in vitro and has afforded some objective responses in individuals with relapsed, refractory MM. However, the activity of PS-341 against non-hematological malignancies remains to be fully elucidated. In this study, we found that PS-341 induced growth arrest and apoptosis of NCI-H520 and -H460 non-small cell lung cancer (NSCLC) cells in conjunction with markedly up… CONTINUE READING
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