Proteasome inhibitor MG132 induces BAG3 expression through activation of heat shock factor 1.

@article{Du2009ProteasomeIM,
  title={Proteasome inhibitor MG132 induces BAG3 expression through activation of heat shock factor 1.},
  author={Z Du and H Zhang and Xin Meng and Yan-yan Gao and Ren-Long Zou and B Liu and Yi-fu Guan and Hua-Qin Wang},
  journal={Journal of cellular physiology},
  year={2009},
  volume={218 3},
  pages={631-7}
}
BAG3 protein, a member of the BAG co-chaperones family, sustains cell survival in a variety of normal and neoplastic cell types, via its interaction with a variety of partners, such as the heat shock protein (HSP) 70, Bcl-2, Raf-1 and others. Expression of BAG3 is induced by some stressful stimuli, such as heat shock, heavy metal exposure. We have reported that proteasome inhibitors can also induce BAG3 expression at the transcriptional level and the induction of BAG3 compromises proteasome… CONTINUE READING